深层过滤系统

Depth Filtration System

The Depth Filtration System is a user-friendly, automated benchtop unit. Equipped with an integrated sensor-laden flow path and TC (Tri-Clamp) fittings compatible with most filter modules, it is widely used for the development of small-scale clarification and pre-filtration processes. It is particularly well-suited for handling high-value products or smaller volumes in clarification and pre-filtration steps. In the biopharmaceutical R&D field, the Depth Filtration System, with its high efficiency, serves as an ideal "lab partner" for daily small-scale clarification and pre-filtration operations.

Advantages

• Extremely low hold-up volume for maximum product recovery

• Optimized flow path design for high filtration efficiency

• Automated operation with high reproducibility

• Reliable performance and easy scalability

• Excellent Human-Machine Interface (HMI)

• Advanced data management capabilities

• Standard international OPC protocol for data exchange and integration with upstream/downstream processes

• Compact, movable design with a small footprint

• Hygienic design, easy to clean, supports CIP (Clean-in-Place) and SIP (Sterilize-in-Place)

• Quick-connect fittings for rapid setup with adjacent equipment and filter modules

• Various specifications available to meet customer needs

Applications

• Harvest of mammalian cell culture broth

• Microbial lysates

• Removal of precipitates from serum and plasma

• Removal of particles and colloids from process intermediates

System Features

Easy-to-Use Operational Interface
The Depth Filtration System is configured with a Siemens industrial PC that starts automatically upon system power-up. Via the touchscreen, users can easily manage and process system control information, conveniently monitor flow rates, temperature, and pressures, view system status, warnings, and alarm indicators, and input commands through the control panel.

Warnings and Alarms
The system can operate automatically at a set constant flow rate. Alarm points for the differential pressure (ΔP) between inlet and outlet can be configured with four types of settings (High/Low and High-High/Low-Low alarms). When a preset High/Low alarm point is reached, the system triggers a warning alert but does not stop operation, allowing for operational adjustments to return to a controlled working range. When a preset High-High/Low-Low alarm point is reached, the system automatically shuts down with an alarm to prevent potential permanent damage. The system is also equipped with an emergency stop button for immediate system halt if necessary.

A P&ID (Piping and Instrumentation Diagram) display monitors and shows all online parameters, including pump speed, feed flow rate, inlet pressure, outlet pressure, feed temperature, and differential pressure (ΔP), enabling easier real-time process monitoring. Parameter trend graphs allow quick review of key parameter changes during operation, providing valuable data support for process development.

Automatic Data Logging and Export
The system automatically logs all operational parameters (e.g., inlet pressure, outlet pressure, differential pressure (ΔP), pump speed, temperature), including time-stamped alarm and event histories for easy future traceability and analysis. Logged data can be saved as SQL database files on the computer and used to generate batch report files directly.

Linear Scalability and Production Condition Simulation
The system uses components standard in industrial production, such as diaphragm pumps and 316L stainless steel fluid pathways. This design simulates production conditions, allowing process simulation at lab scale to ensure smooth process scale-up. For small-scale production, an optional data logger compliant with CFR 21 Part 11 regulations is available.

Depth Filtration System Technical Specifications

深层过滤系统

Depth Filtration Systems

深层过滤系统是一台使用方便的自动化桌面式设备，该设备配置有集成各传感器的管路系统，预留TC接口适用于大多数膜包，使得它被广泛应用于小规模澄清及预过滤工艺的研发，特别适用于高价值产品或较小体积的澄清及预过滤处理。在生物制药研发领域中，深层过滤系统以其高效的性能，成为日常小规模澄清及预过滤操作的理想“实验搭档”。

优势

极低的滞留量，可实现最大的产品回收率  

优化管路设计，过滤效率高

自动操作，可重复性高  

性能可靠，易于放大

良好的人机界面

高级数据管理

标准的国际标准OPC协议，可和前后工艺流程数据交互并联动生产  

设备小巧可移动，占用面积少

卫生设计，易于清洁，支持在线清洗、在线灭菌  

快速接口，可快速和前后设备、膜包等连接使用  

不同规格供客户选择

应用

哺乳动物细胞培养液收获

微生物裂解物

从血清和血浆中除去沉淀物

从工艺中间体中去除颗粒和胶体

系统特点

易于使用的操作界面

深层过滤系统配置西门子工控机，当系统电源打开时自动启动。通过触摸屏，可以轻松管理和处理系统控制信息，例如可以方便地监控流速、温度和压力 ，以及查看系统状态、警告和报警的指示器，并通过控制面板输入命令。

警告和报警

深层过滤系统可在设定的恒定流速下自动运行。对于进料、出料压差 (△P)的报警点，可进行四种设置( 高 / 低报警和超高 / 超低报警 )。当到达预设的高 / 低报警点 (Hi/Lo settings) 时，系统会发出警报并给予提示，但不中止系统运行。此时可改变操作条件，使系统继续运行在可控的工作区域。当到达预设的超高 / 超低报警点

(HiHi/LoLo settings) 时系统会自动停机，并给予警报和提示，以免对系统造成永久损坏。该系统还设有紧急停车按钮，在必要时可立即中止系统运行。

P&ID 流程控制图可监控并显示所有的在线参数，包括泵速、进料流速、进料压力、出口压力、进料温度、压差  (△P)，使您可以更轻松地实时监测工艺参数。您还可以通过参数趋势图，快速查看到关键工艺参数在运行时的变化情况，为工艺开发提供有力的数据支持。

自动数据记录和导出

深层过滤系统可自动记录所有操作参数（进料压力、 出料压力、压差(△P )、泵速、温度、包括警报和事件历史记录）均可由系统自动记录并加入时间标记，方便日后追溯和分析。自动记录的数据可以SQL数据库文件的形式保存至计算机， 并可直接生成批报告文件。

线性放大并模拟生产条件

深层过滤系统使用了常规用于工业生产的配件，如隔膜泵和 316L 不锈钢材质的液体管路。这种模拟生产条件的设计，使您可以在实验室模拟生产条件，从而保证工艺的顺利放大。如需进行小规模生产，可选配符合CFR 21 part 11 标准的数据记录仪。

深层过滤系统技术参数