切向流超滤系统

Tangential Flow Filtration System

The Tangential Flow Filtration System is a user-friendly, automated benchtop device. Configured with proprietary designed cassettes, it is widely used for small-scale ultrafiltration process development and is particularly suited for handling high-value products or smaller volumes. In the biopharmaceutical R&D field, the Tangential Flow Filtration System, with its high-performance efficiency, serves as an ideal partner for daily small-scale ultrafiltration, microfiltration, concentration, and diafiltration (UF/DF) operations.

Advantages

• Extremely low hold-up volume for maximum product recovery

• Automatic Transmembrane Pressure (TMP) / Differential Pressure (DP) control

• Highly compact design with a small footprint

• High efficiency and cost-effectiveness

• Reliable performance with easy scalability

• Modular design with optional online monitoring for pH, conductivity, and UV

• Hygienic design, easy to clean, supports CIP (Clean-in-Place) and SIP (Sterilize-in-Place)

• Versatile design applicable for both ultrafiltration and microfiltration

Applications

• Clarification

• Concentration

• Purification

• Diafiltration / Dialysis

• Batch feeding

System Features

Easy-to-Use Interface
The Tangential Flow Filtration System includes a built-in computer that starts automatically when the system is powered on. Via the touchscreen, users can easily manage pump control information, conveniently monitor flow rates, temperature, and pressures, view system status, warnings, and alarm indicators, and input commands through the control panel.

Warnings and Alarms
The system can operate automatically at set constant pump speed, constant tangential flow, or differential pressure (ΔP). Alarm points can be set for feed, retentate, and permeate pressures, differential pressure (ΔP), and transmembrane pressure (TMP) with four types of settings (High/Low and High-High/Low-Low alarms). When a preset High/Low alarm point is reached, the system triggers a warning alert but does not stop operation, allowing for operational adjustments to return to a controlled working range. When a preset High-High/Low-Low alarm point is reached, the system automatically shuts down with an alarm to prevent potential permanent damage. The system is also equipped with an emergency stop button for immediate system halt if necessary.

A P&ID (Piping and Instrumentation Diagram) display monitors and shows all online parameters, including pump speed, feed flow rate, feed/retentate/permeate pressures, feed temperature, ΔP, TMP, conductivity, pH, and UV, enabling easier real-time process monitoring. Parameter trend graphs allow quick review of key parameter changes during operation, providing valuable data support for process development.

Automatic Data Logging and Export
The system automatically logs all operational parameters (e.g., feed pressure, retentate pressure, permeate pressure, ΔP, TMP, pump speed, temperature, filtrate flow rate, filtrate weight), including time-stamped alarm and event histories for easy future traceability and analysis. Logged data can be saved as SQL database files on the computer and used to generate batch report files directly.

Linear Scalability and Production Condition Simulation
The system uses components standard in industrial production, such as diaphragm pumps and 316L stainless steel fluid pathways. This design simulates production conditions, allowing process simulation at lab scale to ensure smooth process scale-up. For small-scale production, an optional data logger compliant with CFR 21 Part 11 regulations is available.

Technical Specifications

切向流超滤系统

Tangential Flow Filtration System

切向流超滤系统是一台使用方便的自动化台式设备，该设备配置的专有设计膜包，使得它被广泛应用于小规模超滤工艺的研发，特别适用于高价值产品或较小体积的过滤处理。在生物制药研发领域中，切向流超滤系统以其高效的性能，成为日常小规模超滤、微滤、浓缩和透析（UF/DF）操作的理想“实验搭档”。

优势

极低的滞留量，可实现最大的产品回收率

自动跨膜压TMP/DP 控制

高紧凑设计，空间占用小

高效，节约成本

性能可靠，易于放大

模块化设计，可选配在线监测pH、电导率、UV检测等功能  卫生设计，易于清洁，支持在线清洗、在线灭菌

多功能设计可用于超滤和微滤应用

应用

澄清

浓缩

纯化

渗滤/透析    

批生产投料

系统特点

易于使用的操作界面

切向流超滤系统包含一个内置计算机，当系统电源打开时自动启动。通过触摸屏，可以轻松管理和处理泵控制信息，例如可以方便地监控流速、温度和压力 ，以及查看系统状态、警告和报警的指示器，并通过控制面板输入命令。

警告和报警

切向流超滤系统可在设定的恒定泵速、恒定切向流或压差 (△P) 下自动运行。对于进料、回流和透过压力、压差 (△P)、跨膜压 (TMP) 的报警点，可进行四种设置 ( 高 / 低报警和超高 / 超低报警 )。当到达预设的高 /低报警点 (Hi/Lo settings) 时，系统会发出警报并给予提示，但不中止系统运行。此时可改变操作条件，使系统继续运行在可控的工作区域。当到达预设的超高 / 超低报警点 (HiHi/LoLo settings) 时系统会自动停机，并给予警报和提示，以免对系统造成永久损坏。该系统还设有紧急停车按钮，在必要时可立即中止系统运行。

P&ID 流程控制图可监控并显示所有的在线参数，包括泵速、进料流速、进料、回流和透过压力、进料温度、压差(△P)、跨膜压(TMP)、电导、pH、UV，使您可以更轻松地实时监测工艺参数。您还可以通过参数趋势图，快速查看到关键工艺参数在运行时的变化情况，为工艺开发提供有力的数据支持。

自动数据记录和导出

切向流超滤系统可自动记录所有操作参数 ( 进料压力、 回流压力、透过压力、压差、TMP、泵速、温度、滤液流速和滤液重量等 )，包括警报和事件历史记录均可由系统自动记录并加入时间标记，方便日后追溯和分析。自动记录的数据可以SQL数据库文件的形式保存至计算机， 并可直接生成批报告文件。

线性放大并模拟生产条件

切向流超滤系统使用了常规用于工业生产的配件，如隔膜泵和 316L 不锈钢材质的液体管路。这种模拟生产条件的设计，使您可以在实验室模拟生产条件，从而保证工艺的顺利放大。如需进行小规模生产，可选配符合 CFR 21 part 11 标准的数据记录仪。

技术‍参数