Discovery台式纳米颗粒合成系统

Tailored Uniformity • Streamlined Control • Optimal Yield

Discovery Benchtop Research System

The game changing approach to the continuous processing of nanoparticles has become the industry's benchmark. Featuring turbulent jet technology, the  Discovery enables lowest volume research test runs for multi-mode specification and optimization of nanoparticle processing. The  Discovery processing technology can be scaled with system product offerings from clinic to commercial scale

Lipid Nanoparticles (LNPs) 

Liposomes

Nucleic Acid/Lipid Complexes 

Polymeric Micelles

Suspensions

Specifications

Minimum Collection Volume: 2-3 mL (per run)

Solvent Flow Rate: 10 mL/min (nominal)

Flow Rate Ratio: 2-8

E1/A1 Pump Type: Syringe

Dilution Pump Type: Peristaltic (enables 0-350 mL/min)

Operating Temperature Range: 15-30 degrees C

Power Requirements: 110/220 VAC, 200 W max.

 Jet Technology for Highest Precision and Flexibility

The Discovery is a low flow rate, low dead volume system for research nanoparticle processing. To precisely combine genetic material/API in buffer with lipids in solvents, all systems use the  jet mixer, facilitat ing seamless scale-up from R&D to commercial manufacturing

Continuous Manufacturing 

The DISCOVERY enables a direct translation to continuous nanoparticle processing. Batch processes developed on this system scale with the systems

Ease of Use 

Standard connections for syringes, bottles, tubes, or 2D bags. System offers consumable kits for different flow setups

Multiple Program Options 

Create and store runtime recipes to produce particles at different flow conditions and for set durations

Continuous, Single-Pass Platform

The DISCOVERY is linear scalable to the large scale systems, which feature additional inline modules for continuous processing excellence.

Inline Process Analytical Technology

The ground-breaking InProcess-LSP NanoFlowSizer,™ uses SR DLS to offer non-invasive, accurate particle size measurements

Temperature and Sensors

Control the temperature of your sample by adding a TCU along with other custom-integrated sensors to monitor pH and conductivity

Tangential Flow Filtration

The  sp2TFF uses a proprietary multi-stage tangential flow filtration system to reduce biofouling and allow for long runs

Intravesicular & Extravesicular Modifications

The IEM is a continuous processing system for the controlled modification of pre-formed vesicular nanoparticles

定制化均一性 • 精简化控制 • 最优化产出

Discovery 台式研究系统

颠覆性的 纳米粒子连续加工方法已成为行业标杆。Discovery 凭借其专利的湍流喷射技术，能够以极低的样品体积，为纳米粒子加工的多模式规格设定和工艺优化提供研究级测试运行。Discovery 的加工技术可通过 系列系统产品进行放大，从临床规模直至商业化生产规模。

可加工类型包括：

脂质纳米粒 (LNPs)

脂质体

核酸/脂质复合物

聚合物胶束

混悬剂

技术规格

最小收集体积：2-3 mL（每次运行）

溶剂流速：10 mL/分钟（标称值）

流速比：2-8

E1/A1 泵类型：注射泵

稀释泵类型：蠕动泵（可实现 0-350 mL/分钟）

操作温度范围：15-30 摄氏度

电源要求：110/220 VAC，最大功率 200 W

喷射技术，实现最高精度与灵活性

Discovery 是一款低流速、低死体积的纳米粒子研究加工系统。为精确地将缓冲液中的遗传物质/原料药与溶剂中的脂质结合，所有 系统均采用专利的 喷射混合器，从而实现从研发到商业化生产的无缝放大。

连续化生产

DISCOVERY 可直接用于实现纳米粒子的连续化加工。在该系统上开发的批次工艺可通过系统进行放大。

易于使用

提供与注射器、瓶子、管路或 2D 袋的标准连接。可为不同的流速设置提供耗材套件。

多程序选项

创建并存储运行配方，可在不同流速条件下生产纳米粒子，并设定运行时长。

连续、单次通过式平台

DISCOVERY 可线性放大至大型系统，这些大型系统配备了额外的在线模块，以实现卓越的连续加工性能。

在线过程分析技术

开创性的 InProcess-LSP NanoFlowSizer™ 采用静态参考动态光散射技术，提供非侵入式、精确的粒径测量。

温度与传感器

通过添加温度控制单元及其他定制集成传感器，控制样品温度并监测 pH 值和电导率。

切向流过滤

sp2TFF 采用专有的多级切向流过滤系统，可减少生物污染，实现长时间运行。

囊泡内与囊泡外修饰

IEM 是一个连续加工系统，用于对预先形成的囊泡纳米粒子进行可控修饰。